FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation
نویسندگان
چکیده
منابع مشابه
H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for H3K4me1/2 on enhancers remain elusive. Furthermore, how these enzymes function on enhancers to regulate cell-type-specific gene expression is unclear. In this study, we identify MLL4 (KMT2D) as a major ma...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2019
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.06.034